Article
Regulation of IL-6 signaling by p53: STAT3- and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998
Rayanade R J, Ndubuisi M I, Etlinger J D, Sehgal P B
Abstract excerpt
The influence of p53 on cytokine-triggered Janus kinase-STAT signaling was investigated in human hepatoma Hep3B cell lines engineered to constitutively express the temperature-sensitive Val135 mutant of p53. In comparison to the parental p53-free Hep3B cells, these p53-Val135-containing Hep3B cel...
Topics
- Amino Acid Substitution
- Carcinoma, Hepatocellular
- Cytokines
- DNA-Binding Proteins
- Dose-Response Relationship, Immunologic
- Epidermal Growth Factor
- Humans
- Interferon-gamma
- Interleukin-6
- Milk Proteins
- Mutation
- Phenotype
- Phosphatidylinositol Diacylglycerol-Lyase
- Phosphorylation
- STAT3 Transcription Factor
- STAT5 Transcription Factor
- Signal Transduction
- Temperature