Article
STAT5A is regulated by DNA damage via the tumor suppressor p53.
Cytokine - 1 Jun 2016
Mukhopadhyay Utpal K, Cass Jamaica, Raptis Leda, Craig Andrew W, Bourdeau Véronique, Varma Sonal, SenGupta Sandip, Elliott Bruce E, Ferbeyre Gerardo
Abstract excerpt
Here we report that the STAT5A transcription factor is a direct p53 transcriptional target gene. STAT5A is well expressed in p53 wild type cells but not in p53-null cells. Inhibition of p53 reduces STAT5A expression. DNA damaging agents such as doxorubicin also induced STAT5A expression in a p53 dependent manner. Two p53 binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were...
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