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Article

Second generation antitumour human RNase: significance of its structural and functional features for the mechanism of antitumour action.

The Biochemical journal - 15 Aug 2001

Di Gaetano S, D'alessio G, Piccoli R

Abstract excerpt

A second generation mutant of dimeric human pancreas RNase (HHP2-RNase), was obtained by a single residue mutation (Glu(111)-->Gly) of the previously described dimeric human pancreas RNase variant (HHP-RNase). HHP2-RNase was found to be a highly specific antitumour agent, with an enhanced cytotoxic activity compared with HHP-RNase. The structural and functional requisites of the antitumour action of HHP2-RNase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11485573
DOI: 10.1042/0264-6021:3580241
PMCID: PMC1222053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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