Article
A modified cell surface marker gene for transgenic animal studies.
Nucleic acids research - 15 Nov 1998
Kieffer L, Kavathas P B
Abstract excerpt
We developed a marker gene encoding a human cell surface molecule called CD8 for use in transgenic animal studies. The CD8 cDNA contains three mutations: one in the extracellular domain which prevents interaction with its ligand MHC class I and the other two in the cytoplasmic domain which inhibit its signalling function. The cDNA was linked to a fragment of the human growth hormone gene and in transgenic animal...
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