A modified cell surface marker gene for transgenic animal studies.

doi:10.1093/nar/26.22.5228

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Article

A modified cell surface marker gene for transgenic animal studies.

Nucleic acids research - 15 Nov 1998

Kieffer L, Kavathas P B

Abstract excerpt

We developed a marker gene encoding a human cell surface molecule called CD8 for use in transgenic animal studies. The CD8 cDNA contains three mutations: one in the extracellular domain which prevents interaction with its ligand MHC class I and the other two in the cytoplasmic domain which inhibi...

Topics

Animals
Animals, Genetically Modified
Antibodies, Monoclonal
CD8 Antigens
DNA, Complementary
Gene Expression
Genetic Markers
Genetic Vectors
Humans
Lymphocytes
Mutation

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