Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase.

FEBS letters - 17 Sept 2013

Kasymov Rustem D, Grin Inga R, Endutkin Anton V, Smirnov Serge L, Ishchenko Alexander A, Saparbaev Murat K, Zharkov Dmitry O

Abstract excerpt

CpG dinucleotides are targets for epigenetic methylation, many of them bearing 5-methylcytosine (mCyt) in the human genome. Guanine in this context can be easily oxidized to 8-oxoguanine (oxoGua), which is repaired by 8-oxoguanine-DNA glycosylase (OGG1). We have studied how methylation affects the efficiency of oxoGua excision from damaged CpG dinucleotides. Methylation of the adjacent cytosine moderately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methylcytosine
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to DNA Glycosylases

Share to DNA Polymerase II

Share to Epigenesis, Genetic

Share to Guanine

Share to Substrate Specificity

Source

Identifiers

PMID: 23954288
DOI: 10.1016/j.febslet.2013.08.008

Genes

OGG1
APEX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase.PMID 23954288Read ↗

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.Semantic proximity Read ↗

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.Semantic proximity Read ↗

AP endonuclease 1 prevents the extension of a T/G mismatch by DNA polymerase β to prevent mutations in CpGs during base excision repair.Semantic proximity Read ↗

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.Semantic proximity Read ↗

8-oxoguanine DNA glycosylases: one lesion, three subfamilies.Semantic proximity Read ↗

Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk.Semantic proximity Read ↗

DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention.Semantic proximity Read ↗

Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.Semantic proximity Read ↗

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.Semantic proximity Read ↗

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.Semantic proximity Read ↗

The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.Semantic proximity Read ↗

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.