Comparison of chromosome aberration frequency and small-colony TK-deficient mutant frequency in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.

doi:10.1093/mutage/5.6.609

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Article

Comparison of chromosome aberration frequency and small-colony TK-deficient mutant frequency in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.

Mutagenesis - 1 Nov 1990

Moore M M, Doerr C L

Abstract excerpt

The L5178Y/TK(+/-)-3.7.2C mouse lymphoma assay is used to quantitate the induction of thymidine kinase (TK)-deficient mutants. The mutants detected in the assay form colonies that can be distinguished as large or small. The induction of small-colony mutants has been associated with the induction...

Topics

Animals
Cell Line
Chromosome Aberrations
Leukemia L5178
Lymphoma
Mice
Mutagenicity Tests
Mutagens
Mutation
Thymidine Kinase

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