Article
Stability of tk-/- mutants of L5178Y mouse lymphoma cells in Fischer's medium.
Mutation research - 1 Aug 1991
Clive D, Krehl R
Abstract excerpt
The phenotypic stability of over 2000 large- and small-colony trifluorothymidine-resistant (TFTres) variants of L5178Y/tk(+/-)-3.7.2C cells has been examined. All except 4 of 488 spontaneously arising small-colony variants analyzed (0.8%) retained the TFTres phenotype when rechallenged with TFT after growth for several generations in its absence. All of 558 spontaneous large-colony variants, and 440 small-colony...
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