Article
HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians.
The Journal of rheumatology - 1 Sept 2002
Milicic Anita, Lee Dorothea, Brown Matthew A, Darke Chris, Wordsworth B Paul
Abstract excerpt
OBJECTIVE: To elucidate the relative importance of the HLA-DR and HLA-DQ loci in conferring genetic predisposition to rheumatoid arthritis (RA). METHODS: HLA-DRB1 and HLA-DQB1 alleles were typed in a set of 685 patients with RA using sequence-specific polymerase chain reaction. Allele and phenotype frequencies were compared with those in 2 large sets of historical, ethnically matched healthy controls, using the...
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