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Article

Human leukocyte antigen and idiosyncratic adverse drug reactions.

Drug metabolism and pharmacokinetics - 1 Feb 2017

Usui Toru, Naisbitt Dean J

Abstract excerpt

A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. For example, it is well-established that HLA-B*15:02 and HLA-B*57:01 are associated with carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and abacavir-induced...

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Identifiers

PMID: 28017537
DOI: 10.1016/j.dmpk.2016.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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