Article
Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies.
Clinical pharmacology and therapeutics - 1 Oct 1998
Nowak M P, Sellers E M, Tyndale R F
Abstract excerpt
Many human cytochromes P450 (CYP) enzymes are polymorphically expressed, resulting in interindividual and interethnic differences in the metabolism of substrate drugs. Little is known about the genetic variation of CYP enzymes in Canadian Native Indians. We therefore determined the CYP2C19 and CYP2A6 mutant allele frequencies in 159 Canadian Native Indians and compared them with white and Asian subjects. Canadian...
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