Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies.

doi:10.1016/S0009-9236(98)90068-6

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Article

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies.

Clinical pharmacology and therapeutics - 1 Oct 1998

Nowak M P, Sellers E M, Tyndale R F

Abstract excerpt

Many human cytochromes P450 (CYP) enzymes are polymorphically expressed, resulting in interindividual and interethnic differences in the metabolism of substrate drugs. Little is known about the genetic variation of CYP enzymes in Canadian Native Indians. We therefore determined the CYP2C19 and CY...

Topics

Alleles
Aryl Hydrocarbon Hydroxylases
Asian People
Canada
Cytochrome P-450 CYP2A6
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Indians, North American
Male
Mixed Function Oxygenases
Mutation
White People

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