The influence of the hinge region length in binding of human IgG to human Fcγ receptors

doi:10.1016/s0198-8859(98)00075-5

Article

The influence of the hinge region length in binding of human IgG to human Fcγ receptors

1 Nov 1998

Abstract excerpt

Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa but was more potent at activating ADCC by activated lymphocytes (FcgammaRIIIa-mediated),...

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