Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG.

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Article

Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1991

Lund J, Winter G, Jones P T, Pound J D, Tanaka T, Walker M R, Artymiuk P J, Arata Y, Burton D R, Jefferis R

Abstract excerpt

Cellular receptors for IgG (Fc gamma R) mediate important protective functions. By using site-specific mutants of a chimeric antibody (mouse V H domain and L chain; human IgG3 C H domains), we have demonstrated that human Fc gamma RI interacts with a site in the lower hinge of human IgG (residues...

Topics

Antigens, Differentiation
Binding Sites
Humans
Immunoglobulin G
In Vitro Techniques
Mutation
Receptors, Fc
Receptors, IgG
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 1833457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1833457-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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