Article
Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction.
Oxidative medicine and cellular longevity - 1 Jan 2016
Perrone Serafina, Lotti Federica, Geronzi Ursula, Guidoni Elisa, Longini Mariangela, Buonocore Giuseppe
Abstract excerpt
Oxidative stress is a distinctive sign in several genetic disorders characterized by cancer predisposition, such as Ataxia-Telangiectasia, Fanconi Anemia, Down syndrome, progeroid syndromes, Beckwith-Wiedemann syndrome, and Costello syndrome. Recent literature unveiled new molecular mechanisms linking oxidative stress to the pathogenesis of these conditions, with particular regard to mitochondrial dysfunction....
Topics
- Age Factors
- Animals
- Anticarcinogenic Agents
- Antioxidants
- Beckwith-Wiedemann Syndrome
- Cell Transformation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Mitochondria
- Mitochondrial Diseases
- Neoplasms
- Oxidative Stress
- Prader-Willi Syndrome