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Article

Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients.

Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2011

Lee J Jack, Wu Xifeng, Hildebrandt Michelle A T, Yang Hushan, Khuri Fadlo R, Kim Edward, Gu Jian, Ye Yuanqing, Lotan Reuben, Spitz Margaret R, Hong Waun Ki

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) patients are at an increased risk of developing a second primary tumor (SPT) or recurrence following curative treatment. 13-cis-retinoic acid (13-cRA) has been tested in chemoprevention clinical trials, but the results have been inconclusive. We genot...

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Share to Carcinoma, Squamous Cell
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Neoplasm Recurrence, Local

Share to Neoplasms, Second Primary

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Share to Retinoid X Receptor alpha

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Source

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Identifiers

PMID: 21292633
DOI: 10.1158/1940-6207.CAPR-10-0125
PMCID: PMC3955084

Genes

JAK2
RXRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21292633-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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