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Article

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.

Chemico-biological interactions - 15 Dec 2005

Hrabovska Anna, Duysen Ellen G, Sanders Jeffrey D, Murrin L Charles, Lockridge Oksana

Abstract excerpt

The purpose of this work was to develop a gene delivery system that expressed acetylcholinesterase (AChE) for prolonged periods. An adeno-associated virus (AAV) expressing human AChE was constructed by co-transfecting three plasmids into HEK 293T cells. The purified vector expressed 0.17 microg AChE per 1 million viral particles in culture medium in 23 h, or 0.8 U/ml. The AAV/hAChE was injected into muscle of...

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Identifiers

PMID: 16243306
DOI: 10.1016/j.cbi.2005.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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