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Article

Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model.

Scientific reports - 30 Jul 2018

Zhao J, Cooper L T, Boyd A W, Bartlett P F

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an untreatable, progressive, neurodegenerative disease specifically affecting motor neurons. Recently, the tyrosine kinase receptor EphA4 was directly implicated in ALS disease progression. We report that a long-lived mutated form of the EphA4 antagonist EphA4-Fc (mutEphA4-Fc), which blocks EphA4 binding to its ligands and inhibits its function, significantly improved...

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Identifiers

PMID: 30061574
DOI: 10.1038/s41598-018-29845-1
PMCID: PMC6065374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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