Article
Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family.
The Journal of clinical investigation - 15 Oct 1998
Verge C F, Vardi P, Babu S, Bao F, Erlich H A, Bugawan T, Tiosano D, Yu L, Eisenbarth G S, Fain P R
Abstract excerpt
Based on a genomic search for linkage, a locus contributing to type 1 diabetes in a large Bedouin Arab family (19 affected relatives) maps to the long arm of chromosome 10 (10q25; nonparametric linkage = 4.99; P = 0.00004). All affected relatives carry one or two high-risk HLA-DR3 haplotypes that...
Topics
- Arabs
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Diabetes Mellitus, Type 1
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- HLA-DR3 Antigen
- Haplotypes
- Humans
- Israel
- Pedigree
- White People