Article
Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family.
Annals of the New York Academy of Sciences - 1 Nov 2003
Babu Sunanda R, Bao Fei, Roberts Christine M, Martin Allison K, Gowan Katherine, Eisenbarth George S, Fain Pamela R
Abstract excerpt
The IDDM 17 locus was mapped to an 8-cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7 (CASP7), an apoptosis-related cysteine protease, is one of the few known genes in this region. CASP7 is involved in the activation cascade of caspases responsible for apoptosis execution. Only 1 of the 18 SNPs in CASP7 (SNP144692) differed significantly in...
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