Article
IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family.
Annals of the New York Academy of Sciences - 1 Dec 2004
Eller Elise, Vardi Pnina, Daly Mark J, Babu Sunanda, Roberts Christine, Yang Fan, Eisenbarth George S, Fain Pamela R
Abstract excerpt
Haplotype blocks characterized from 78 single-nucleotide polymorphisms (SNPs) in a 1- to 2-centiMorgan region in the human diabetes susceptibility gene IDDM17 were tested for association with type 1 diabetes mellitus (T1DM). Two haplotypes in two adjacent blocks in AMACO, a von Willebrand factor homologue, appear to be associated with the absence of T1DM; transmission tests support this hypothesis. Interestingly,...
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