Article
Mutants in trs120 disrupt traffic from the early endosome to the late Golgi.
The Journal of cell biology - 5 Dec 2005
Cai Huaqing, Zhang Yueyi, Pypaert Marc, Walker Lee, Ferro-Novick Susan
Abstract excerpt
Transport protein particle (TRAPP), a large complex that mediates membrane traffic, is found in two forms (TRAPPI and -II). Both complexes share seven subunits, whereas three subunits (Trs130p, -120p, and -65p) are specific to TRAPPII. Previous studies have shown that mutations in the TRAPPII-specific gene trs130 block traffic through or from the Golgi. Surprisingly, we report that mutations in trs120 do not...
Topics
- Coat Protein Complex I
- Endosomes
- Golgi Apparatus
- Guanine Nucleotide Exchange Factors
- Membrane Proteins
- Microscopy, Electron, Transmission
- Mutation
- Protein Subunits
- Protein Transport
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Vesicular Transport Proteins