Article
Attenuated mutants of Staphylococcus aureus with two temperature-sensitive lesions: isolation and characterization.
Microbios - 1 Jan 1998
Sordelli D O, Cerquetti M C, Buzzola F R, García V E, Gómez M I, Morris Hooke A
Abstract excerpt
The feasibility of constructing attenuated mutants of Staphylococcus aureus with two temperature-sensitive (ts) lesions for ultimate development of a live-attenuated strain was investigated. Temperature-sensitive S. aureus strain G/1/2, which grows well at 31 degrees C but does not replicate at 3...
Topics
- Animals
- Bacterial Vaccines
- Cattle
- Hot Temperature
- Nitroso Compounds
- Phenotype
- Point Mutation
- Sensitivity and Specificity
- Staphylococcal Infections
- Staphylococcus aureus
- Vaccines, Attenuated