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Article

Attenuated mutants of Staphylococcus aureus with two temperature-sensitive lesions: isolation and characterization.

Microbios - 1 Jan 1998

Sordelli D O, Cerquetti M C, Buzzola F R, García V E, Gómez M I, Morris Hooke A

Abstract excerpt

The feasibility of constructing attenuated mutants of Staphylococcus aureus with two temperature-sensitive (ts) lesions for ultimate development of a live-attenuated strain was investigated. Temperature-sensitive S. aureus strain G/1/2, which grows well at 31 degrees C but does not replicate at 37 degrees C, was subjected to chemical mutagenesis. After two enrichment cycles, fifteen mutants able to grow at 25...

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PMID: 9785488

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