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Article

Immunization with temperature-sensitive mutants of Salmonella typhi induces protection in mice.

Vaccine - 1 Apr 1991

Hooke A M, Wang Z, Cerquetti M C, Bellanti J A

Abstract excerpt

Temperature-sensitive (TS) mutants of Salmonella typhi were isolated following mutagenesis with nitrosoguanidine and two cycles of enrichment with penicillin and D-cycloserine. Several of the TS mutants were characterized with respect to growth profiles at permissive (29 degrees C) and non-permissive (36 degrees C) temperatures, reversion rates, and the potential for inducing protection against challenge in an...

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Source

Identifiers

PMID: 2058266
DOI: 10.1016/0264-410x(91)90106-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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