Immunization with temperature-sensitive mutants of Salmonella typhi induces protection in mice.

doi:10.1016/0264-410x(91)90106-g

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Article

Immunization with temperature-sensitive mutants of Salmonella typhi induces protection in mice.

Vaccine - 1 Apr 1991

Hooke A M, Wang Z, Cerquetti M C, Bellanti J A

Abstract excerpt

Temperature-sensitive (TS) mutants of Salmonella typhi were isolated following mutagenesis with nitrosoguanidine and two cycles of enrichment with penicillin and D-cycloserine. Several of the TS mutants were characterized with respect to growth profiles at permissive (29 degrees C) and non-permis...

Topics

Animals
Antibodies, Bacterial
Bacterial Vaccines
Male
Mice
Mice, Inbred BALB C
Mutation
Phenotype
Salmonella typhi
Temperature
Typhoid Fever
Vaccines, Attenuated

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