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Isolation and characterization of temperature-sensitive mutants of the Staphylococcus aureus dnaC gene.

FEMS microbiology letters - 23 Apr 2002

Kaito Chikara, Kurokawa Kenji, Hossain Muktadir Shahid, Akimitsu Nobuyoshi, Sekimizu Kazuhisa

Abstract excerpt

A protein encoded by the Staphylococcus aureus dnaC gene has 44% and 58% homology with Escherichia coli DnaB and Bacillus subtilis DnaC replicative DNA helicases, respectively. We identified five mutant strains whose temperature-sensitive colony formation phenotypes were complemented by the dnaC gene. DNA replication in these mutants has a fast-stop phenotype, indicating that the S. aureus dnaC gene encodes the...

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PMID: 12023093
DOI: 10.1111/j.1574-6968.2002.tb11175.x

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