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Article

Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus.

Vaccine - 1 Dec 1996

Tolley K P, Marriott A C, Simpson A, Plows D J, Matthews D A, Longhurst S J, Evans J E, Johnson J L, Cane P A, Randolph V B, Easton A J, Pringle C R

Abstract excerpt

The nucleotide sequences of the genome of the RSS-2 wild type strain of respiratory syncytial (RS) virus, which is known to induce upper respiratory tract infection in adults, and that of the attenuated ts1C candidate vaccine derived from it by three cycles of mutagenesis and selection of tempera...

Topics

Adult
Animals
Bronchiolitis
Cloning, Molecular
Codon
Genome, Viral
Humans
Infant
Mutation
Paramyxoviridae
Reference Values
Respiratory Syncytial Virus, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Sigmodontinae

Virulence

Source

Identifiers

PMID: 9032893
DOI: 10.1016/s0264-410x(96)00136-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9032893-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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