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Article

Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus.

Vaccine - 1 Dec 1996

Tolley K P, Marriott A C, Simpson A, Plows D J, Matthews D A, Longhurst S J, Evans J E, Johnson J L, Cane P A, Randolph V B, Easton A J, Pringle C R

Abstract excerpt

The nucleotide sequences of the genome of the RSS-2 wild type strain of respiratory syncytial (RS) virus, which is known to induce upper respiratory tract infection in adults, and that of the attenuated ts1C candidate vaccine derived from it by three cycles of mutagenesis and selection of temperature-sensitive (ts) mutants, have been determined. Comparison of the sequences has located the genetic changes which...

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Identifiers

PMID: 9032893
DOI: 10.1016/s0264-410x(96)00136-3

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