Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus

6 Aug 2015

Abstract excerpt

UNLABELLED: The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate immune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely affects viral host range and pathogenesis. While the monkeypox virus (MPXV) genome encodes a homologue of the VACV E3 protein, encoded by the F3L gene, the MPXV gene is predicted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to Poxvirus research and outbreaks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26246580
DOI: 10.1128/jvi.00304-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evasion of the Innate Immune Type I Interferon System by Monkeypox VirusPMID 26246580Read ↗

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus PathogenicitySemantic proximity Read ↗

The monkeypox virus-host interplaysSemantic proximity Read ↗

Poxvirus Driven Human Diseases and Emerging TherapeuticsSemantic proximity Read ↗

The nuclear localization signal of monkeypox virus protein P2 orthologue is critical for inhibition of IRF3-mediated innate immunitySemantic proximity Read ↗

The Global Health Threat of Monkeypox Virus: Understanding Its Biology, Transmission, and Potential Therapeutic InterventionsSemantic proximity Read ↗

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase ActivationSemantic proximity Read ↗

Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes.Semantic proximity Read ↗

Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genesSemantic proximity Read ↗

The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapiesSemantic proximity Read ↗

C7L Family of Poxvirus Host Range Genes Inhibits Antiviral Activities Induced by Type I Interferons and Interferon Regulatory Factor 1Semantic proximity Read ↗

From Entry to Evasion: A Comprehensive Analysis of Host-Virus Interactions for MonkeypoxSemantic proximity Read ↗

Monkeypox virus and insights into its immunomodulatory proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.