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Replicating poxviruses for human cancer therapy

1 Apr 2015

Abstract excerpt

Naturally occurring oncolytic viruses are live, replication-proficient viruses that specifically infect human cancer cells while sparing normal cell counterparts. Since the eradication of smallpox in the 1970s with the aid of vaccinia viruses, the vaccinia viruses and other genera of poxviruses have shown various degrees of safety and efficacy in pre-clinical or clinical application for human anti-cancer...

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PMID: 25845536
DOI: 10.1007/s12275-015-5041-4

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