Article
Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998
Zhang J, Kimura T, Siraganian R P
Abstract excerpt
The protein tyrosine kinase Syk plays a pivotal role in mediating the high-affinity IgE receptor (Fc epsilonRI)-induced degranulation of mast cells. To examine the mechanism of Syk regulation, the two tyrosine residues at 519 and 520 in the putative activation loop of rat Syk were mutated to phen...
Topics
- Animals
- Binding Sites
- Cell Degranulation
- Enzyme Precursors
- Intracellular Signaling Peptides and Proteins
- Mast Cells
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Rats
- Receptors, IgE
- Signal Transduction
- Syk Kinase