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Article

Structural and biophysical characterization of the Syk activation switch.

Journal of molecular biology - 23 Jan 2013

Grädler Ulrich, Schwarz Daniel, Dresing Verena, Musil Djordje, Bomke Jörg, Frech Matthias, Greiner Hartmut, Jäkel Stefan, Rysiok Thomas, Müller-Pompalla Dirk, Wegener Ansgar

Abstract excerpt

Syk is an essential non-receptor tyrosine kinase in intracellular immunological signaling, and the control of Syk kinase function is considered as a valuable target for pharmacological intervention in autoimmune or inflammation diseases. Upon immune receptor stimulation, the kinase activity of Sy...

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Share to Phosphotyrosine
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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23154170
DOI: 10.1016/j.jmb.2012.11.007

Genes

PNP
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23154170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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