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Article

Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk.

The Journal of biological chemistry - 17 Oct 2008

Yamashita Toshiyuki, Suzuki Ryo, Backlund Peter S, Yamashita Yumi, Yergey Alfred L, Rivera Juan

Abstract excerpt

The cell surface-expressed gamma chain of the high affinity receptor for IgE (FcepsilonRI) can be phosphorylated on two tyrosine residues of the immunoreceptor tyrosine-based activation motif (ITAM), leading to recruitment and activation of spleen tyrosine kinase (Syk), a kinase that is essential for mast cell signaling and allergic responses. However, it is not known whether preferential phosphorylation or...

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Identifiers

PMID: 18715866
DOI: 10.1074/jbc.M802679200
PMCID: PMC2568911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk.PMID 18715866Read ↗

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