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Article

Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.

BMC immunology - 6 Dec 2002

Hsueh Robert C, Hammill Adrienne M, Lee Jamie A, Uhr Jonathan W, Scheuermann Richard H

Abstract excerpt

BACKGROUND: Immature B lymphocytes and certain B cell lymphomas undergo apoptotic cell death following activation of the B cell antigen receptor (BCR) signal transduction pathway. Several biochemical changes occur in response to BCR engagement, including activation of the Syk tyrosine kinase. Although Syk activation appears to be necessary for some downstream biochemical and cellular responses, the signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12470302
DOI: 10.1186/1471-2172-3-16
PMCID: PMC139997

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.PMID 12470302Read ↗

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SYK inhibition and response prediction in diffuse large B-cell lymphomaSemantic proximity Read ↗

Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity.Semantic proximity Read ↗

Cutting Edge: Constitutive B Cell Receptor Signaling Is Critical for Basal Growth of B LymphomaSemantic proximity Read ↗

Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.Semantic proximity Read ↗

Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

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