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Article

Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations.

Vaccine - 5 Nov 2008

Yu Li, Robert Putnak J, Pletnev Alexander G, Markoff Lewis

Abstract excerpt

Four viable West Nile (WN) 3'SL-mutant viruses were evaluated for neuroinvasiveness and neurovirulence in mice. All mutants were highly attenuated for neuroinvasiveness. However, only one of these four (WNmutE virus) was significantly attenuated for neurovirulence. To attenuate WNmutE virus further, we introduced five substitution mutations into the envelope (env) gene segment in wild-type (wt) WN and WNmutE...

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Source

Identifiers

PMID: 18805457
DOI: 10.1016/j.vaccine.2008.08.064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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