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Article

Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice.

Archives of virology - 1 Jan 1994

Halevy M, Akov Y, Ben-Nathan D, Kobiler D, Lachmi B, Lustig S

Abstract excerpt

The neuropathogenicity of West Nile virus (WNV) and two derived attenuated strains WN25 and WN25A, was studied in young adult ICR mice and in severe combined immunodeficient (SCID) mice. Similarity in serology and RNA fingerprints were found between WNV and WN25. The viral envelope proteins of th...

Topics

Aedes
Animals
B-Lymphocytes
Brain
Cell Line
Female
Injections, Intraperitoneal
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Mice, Nude
Mice, SCID
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Serial Passage

Viral Envelope Proteins

Virulence

Virus Replication

Source

Identifiers

PMID: 7944955
DOI: 10.1007/BF01309481

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7944955-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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