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Article

Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.

Virology - 10 May 2008

Růzek Daniel, Gritsun Tamara S, Forrester Naomi L, Gould Ernest A, Kopecký Jan, Golovchenko Maryna, Rudenko Nataliia, Grubhoffer Libor

Abstract excerpt

An attenuated strain (263) of the tick-borne encephalitis virus, isolated from field ticks, was either serially subcultured, 5 times in mice, or at 40 degrees C in PS cells, producing 2 independent strains, 263-m5 and 263-TR with identical genomes; both strains exhibited increased plaque size, neuroinvasiveness and temperature-resistance. Sequencing revealed two unique amino acid substitutions, one mapping close...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Animals, Suckling
Base Sequence
Brain
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
Europe
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred ICR

Models, Molecular

Mutation

RNA Helicases

Selection, Genetic

Sequence Analysis, DNA

Serial Passage

Source

Identifiers

PMID: 18339416
DOI: 10.1016/j.virol.2008.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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