Article
Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds.
The American journal of tropical medicine and hygiene - 1 Apr 2010
Murata Ryo, Eshita Yuki, Maeda Akihiko, Maeda Junko, Akita Saki, Tanaka Tomohisa, Yoshii Kentaro, Kariwa Hiroaki, Umemura Takashi, Takashima Ikuo
Abstract excerpt
Many West Nile (WN) virus isolates associated with significant outbreaks possess a glycosylation site on the envelope (E) protein. E-protein glycosylated variants of New York (NY) strains of WN virus are more neuroinvasive in mice than the non-glycosylated variants. To determine how E protein glycosylation affects the interactions between WN virus and avian hosts, we inoculated young chicks with NY strains of WN...
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