Article
The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes.
The American journal of pathology - 1 Oct 1998
Oliveira C, Seruca R, Seixas M, Sobrinho-Simões M
Abstract excerpt
Gastric carcinomas with DNA replication errors (RER phenotype) display a particular clinicopathologic profile and carry a putative favorable prognosis. The RER phenotype has been identified as microsatellite instability in noncoding regions, as well as in repeat sequences within exons of several...
Topics
- Aged
- DNA Primers
- DNA Repair
- DNA Replication
- DNA, Neoplasm
- DNA, Satellite
- Female
- Genetic Markers
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation
- Prognosis