Article
The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease.
Molecular psychiatry - 1 Sept 1998
Oliveira J R, Gallindo R M, Maia L G, Brito-Marques P R, Otto P A, Passos-Bueno M R, Morais M A, Zatz M
Abstract excerpt
We analyzed a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTTPLR) in 81 patients with late onset Alzheimer's (AD) disease (mean age 70.02 +/- 8.13 years). Control groups included 81 normal subjects with comparable age (mean age 75.6 +/- 10.2) an...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Alzheimer Disease
- Carrier Proteins
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Membrane Glycoproteins
- Membrane Transport Proteins