Article
The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease.
Molecular psychiatry - 1 Sept 1998
Oliveira J R, Gallindo R M, Maia L G, Brito-Marques P R, Otto P A, Passos-Bueno M R, Morais M A, Zatz M
Abstract excerpt
We analyzed a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTTPLR) in 81 patients with late onset Alzheimer's (AD) disease (mean age 70.02 +/- 8.13 years). Control groups included 81 normal subjects with comparable age (mean age 75.6 +/- 10.2) and 82 younger normal subjects (mean age 37.4 +/- 9.1). Statistical analysis showed a significant difference in the...
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