Article
Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease.
Neuroreport - 10 Feb 1997
Li T, Holmes C, Sham P C, Vallada H, Birkett J, Kirov G, Lesch K P, Powell J, Lovestone S, Collier D
Abstract excerpt
We examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reduction in expression of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. The frequency of the 484 bp low activity allele was elevated in the subjects with AD (p = 0.004), and an excess of the low activity genotype (30%) was also found in comparison...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.