Article
Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease.
Neuroreport - 10 Feb 1997
Li T, Holmes C, Sham P C, Vallada H, Birkett J, Kirov G, Lesch K P, Powell J, Lovestone S, Collier D
Abstract excerpt
We examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reduction in expression of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. The frequency of the 484 bp low activity allele was eleva...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Carrier Proteins
- DNA Primers
- DNA Transposable Elements
- Disease Susceptibility
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Lymphocytes
- Membrane Glycoproteins
- Membrane Transport Proteins
- Middle Aged