Article
Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association.
American journal of medical genetics - 12 Jun 2000
Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S
Abstract excerpt
Recently two independent research groups consistently reported a significant association between the serotonin transporter (5-HTT) gene and late-onset sporadic Alzheimer's disease (AD). They found that the "short" allele of the 5-HTT gene-linked polymorphic region (5-HTTLPR), which is associated with reduced transcriptional activity of the gene, increases the risk of developing late-onset AD. The present study...
Topics
- Age of Onset
- Aged
- Alleles
- Alzheimer Disease
- Carrier Proteins
- Female
- Genetic Predisposition to Disease
- Humans
- Japan
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Middle Aged
- Nerve Tissue Proteins