Article
The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease.
International psychogeriatrics - 1 Dec 2001
Sweet R A, Pollock B G, Sukonick D L, Mulsant B H, Rosen J, Klunk W E, Kastango K B, DeKosky S T, Ferrell R E
Abstract excerpt
BACKGROUND: Psychotic symptoms in subjects with Alzheimer disease (AD+psychosis, AD+P) are a marker for a distinct phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. We recently found that AD subjects homozygous for long alleles (l) of an insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTPR) had elevated rates of...
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