Article
No association between familial Alzheimer disease and cytochrome P450 polymorphisms.
Alzheimer disease and associated disorders - 1 Sept 1998
Yamada H, Dahl M L, Viitanen M, Winblad B, Sjöqvist F, Lannfelt L
Abstract excerpt
Four different loci have been found to be involved in the development of familial Alzheimer disease (AD). The epsilon4 allele of the apolipoprotein E gene on chromosome 19 is a susceptibility factor for AD, and in a small number of AD families, dominant mutations with high penetrance are operatin...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Parkinson Disease
- Polymorphism, Genetic