Article
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Pharmacological research - 1 Feb 2006
Scordo Maria Gabriella, Dahl Marja-Liisa, Spina Edoardo, Cordici Francesco, Arena Maria Grazia
Abstract excerpt
Allelic variation at the CYP2D6 gene has been suggested to be associated with CNS disorders, including Parkinson's disease and Lewy body dementia. In order to elucidate whether a relationship exists between CYP2D6 polymorphism and the risk of developing Alzheimer's disease (AD), CYP2D6 allele and genotype frequencies have been evaluated in 94 patients from Southern Italy (29 men and 65 women, aged 74+/-8 years)...
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