Article
The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families.
Arthritis and rheumatism - 1 Nov 2003
Ogilvie Emma M, Fife Mark S, Thompson Susan D, Twine Natalie, Tsoras Monica, Moroldo Marta, Fisher Sheila A, Lewis Cathryn M, Prieur Anne-Marie, Glass David N, Woo Patricia
Abstract excerpt
OBJECTIVE: Levels of interleukin-6 (IL-6) have been shown to correlate with the fever and disease activity of systemic juvenile idiopathic arthritis (JIA). In a previous case-control study, a significant association between the IL-6 -174 nucleotide variant and systemic JIA was noted, and HeLa cell transfection assays show functional differences in levels of transcription of the IL-6 -174 alleles. The present...
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