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Article

Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency.

International journal of molecular sciences - 19 Jul 2022

Rigoli Marta, Spagnolli Giovanni, Lorengo Giulia, Monti Paola, Potestio Raffaello, Biasini Emiliano, Inga Alberto

Abstract excerpt

The formation of a tetrameric assembly is essential for the ability of the tumor suppressor protein p53 to act as a transcription factor. Such a quaternary conformation is driven by a specific tetramerization domain, separated from the central DNA-binding domain by a flexible linker. Despite the distance, functional crosstalk between the two domains has been reported. This phenomenon can explain the pathogenicity...

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Identifiers

PMID: 35887312
DOI: 10.3390/ijms23147960
PMCID: PMC9316806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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