Article

Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency

2022-05-13

Abstract excerpt

<h4>ABSTRACT</h4> The formation of a tetrameric assembly is essential for the ability of the tumor suppressor protein p53 to act as a transcription factor. Such a quaternary conformation is driven by a specific tetramerization domain, separated from the central DNA binding domain by a flexible linker. Despite the distance, functional crosstalk between the two domains has been reported. This phenomenon can explain...

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Literature Corpus work: 99336e53-c283-510e-a203-41423d89abde
DOI: 10.1101/2022.05.13.491836

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