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Article

p53 mutants without a functional tetramerisation domain are not oncogenic.

Journal of molecular biology - 12 Mar 1999

Chène P, Bechter E

Abstract excerpt

p53 is altered in about 50 % of cancers. Most of the p53 mutants have lost the wild-type tumour suppressor activity but show oncogenic properties. The majority of the p53 alterations are missense mutations of residues located in its DNA binding domain (DBD). Only a few mutations concern residues...

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Identifiers

PMID: 10064694
DOI: 10.1006/jmbi.1999.2563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10064694-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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p53 mutants without a functional tetramerisation domain are not oncogenic.PMID 10064694Read ↗

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