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Article

Dissection of functional domains of the pituitary-specific transcription factor GHF-1.

Nature - 1 Jan 2000

Theill L E, Castrillo J L, Wu D, Karin M

Abstract excerpt

The specific expression of growth hormone (GH) in the somatotrophic cells of the anterior pituitary is largely attributable to a short promoter in the 5' flanking region of the GH gene. This promoter contains two binding sites for the transcription factor GHF-1, the expression of which is also specific to cells of the somatotrophic lineage and correlates with activation of the GH gene in the developing mouse...

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Identifiers

PMID: 2574416
DOI: 10.1038/342945a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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