Article
Dissection of functional domains of the pituitary-specific transcription factor GHF-1.
Nature - 1 Jan 2000
Theill L E, Castrillo J L, Wu D, Karin M
Abstract excerpt
The specific expression of growth hormone (GH) in the somatotrophic cells of the anterior pituitary is largely attributable to a short promoter in the 5' flanking region of the GH gene. This promoter contains two binding sites for the transcription factor GHF-1, the expression of which is also specific to cells of the somatotrophic lineage and correlates with activation of the GH gene in the developing mouse...
Topics
- Amino Acid Sequence
- Chromosome Deletion
- Cloning, Molecular
- DNA-Binding Proteins
- Genes, Homeobox
- Genetic Vectors
- Growth Hormone
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Pituitary Gland, Anterior