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Article

Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene.

1 Dec 1993

Abstract excerpt

The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid transcription factor 1 (TTF1), a transcription factor essential for thyroid-specific gene expression, binds to the TSHr minimal promoter. The promoter, when mutated at...

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PMID: 8145764
DOI: 10.1210/mend.7.12.8145764

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