Article
Bax cleavage is mediated by calpain during drug-induced apoptosis.
Oncogene - 3 Sept 1998
Wood D E, Thomas A, Devi L A, Berman Y, Beavis R C, Reed J C, Newcomb E W
Abstract excerpt
The anti-apoptotic molecule Bcl-2 is located in the mitochondrial and endoplasmic reticulum membranes as well as the nuclear envelope. Although its location has not been as rigorously defined, the pro-apoptotic molecule Bax appears to be mainly a cytosolic protein which translocates to the mitoch...
Topics
- Alanine
- Amino Acid Sequence
- Apoptosis
- Aspartic Acid
- Binding Sites
- Calpain
- Camptothecin
- Cell Death
- Cell Extracts
- Cell Membrane
- Cysteine Proteinase Inhibitors
- Dipeptides
- HL-60 Cells
- Humans
- Hydrolysis
- Leucine
- Molecular Sequence Data
- Mutation