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Article

HIV-1 protease-induced apoptosis

20 May 2014

Abstract excerpt

BACKGROUND: Apoptosis is one of the presumptive causes of CD4+ T cell depletion during HIV infection and progression to AIDS. However, the precise role of HIV-1 in this process remains unexplained. HIV-1 protease (PR) has been suggested as a possible factor, but a direct link between HIV-1 PR enzymatic activity and apoptosis has not been established. RESULTS: Here, we show that expression of active HIV-1 PR...

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PMID: 24886575
DOI: 10.1186/1742-4690-11-37

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