Article

TRAIL induces caspase-dependent cleavage of specific components of the clathrin-mediated endocytosis machinery

2024-10-24

Abstract excerpt

<h4>ABSTRACT</h4> It has been reported that caspase activation by the proapoptotic ligand Apo2L/TRAIL disrupts the clathrin-mediated endocytosis machinery (CMEM). To confirm whether TRAIL induces caspase-mediated cleavage of specific CMEM components, we examined the temporal and functional relationship between TRAIL-induced processing of the apoptosis-initiating protease, caspase-8, and the apoptosis-executing pr...

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Literature Corpus work: bce62135-4a9b-5311-995c-8b24f220020f
DOI: 10.1101/2024.10.24.619217

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